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Real World Evidence Definition

Real World Evidence Definition

Real World Evidence is information on health care that is derived from multiple sources outside typical clinical research settings, including electronic health records (EHRs), claims and billing data, product and disease registries, and data gathered through personal devices and health applications.

The most quoted definition of Real World Data comes from the area of pharmacoeconomics. The ISPOR (International Society for Pharmacoeconomics and Outcomes Research) defines Real World Data as:

“Data used for decision making that are not collected in conventional randomized controlled trials (RCTs)”

Other definitions of Real World Data, Real World Evidence and Evidence from Clinical Experience can be found in the following figure, taken from a working paper of the Margolis Center for Health Policy, Duke University (see References below).

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